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Anti-Androgen Receptor(AR) antibody [ABT-AR]

Catalog No : V0007
  • Applications
    IHC, WB
  • Host Species
    Mouse
  • Reactivity
    Human
  • Size
    50ul
  • Price
    $175.00
Anti-Androgen Receptor also known as ANDR, Androgen receptor, DHTR, Dihydrotestosterone receptor, NR3C4 is designed to recognize specifically the human androgen receptors with the antibody also cross-reacting with the rat androgen receptor.
Androgens are the sex hormones in male (dehydroepiandrosterone, dihydrotestosterone, testosterone and androstenedione) which provides the transcriptional and  that exert biological impacts when it binds to the nuclear androgen receptor (AR). This is a nuclear receptor which is inducible by ligands and expressed on cardiovascular tissue, hair follicles, genital organs, skeletal muscles, bone and brain. The AR get internalized after binding to the androgen and start modulating the transcription process of the target genes. It also promotes extra-nuclear processes where it induces rapidly the signalling cascades of protein kinase C and MAPK. Therefore permanent sexual differentiation of the sex organs can be achieved through AR regulation during embryogenesis and puberty when sex-specific characteristics get developed.
Details
  • Product Name
    Anti-Androgen Receptor(AR) antibody [ABT-AR]
  • Catalog No
    V0007
  • Description
    Mouse monoclonal [ABT-AR] antibody to AR
  • Applications
    IHC, WB
  • Clonality
    Monoclonal
  • Host Species
    Mouse
  • Reactivity
    Human
  • ABT Clone ID
    ABT-AR
  • Antigen Retrieval
    Heat-induced epitope retrieval (HIER)
  • Cell Marque/Ventana Control
    Prostate
  • Dilution
    1:50-200
  • Entrez Gene ID (NCBI)
    367
  • IHC Recommended control
    Normal Prostate, Prostatic carcinoma
  • IHC Target Name
    Androgen Receptor(AR)
  • Immunogen
    Synthetic peptide
  • Localization
    Nuclear
  • OMIM
    313700
  • Purification
    Immunogen affinity purified
  • Research
    Prostate: prostate carcinoma, benign, Salivary Duct Carcinoma, breast carcinoma, prostate carcinoma, basal cell carcinoma, sebaceous carcinoma
  • Retrieval buffer
    TRIS-EDTA of pH8.0
  • Source/Ig Isotype
    Mouse IgG
  • Storage/Stablility
    -20°C/1 year
  • Synonyms
    ANDR, Androgen receptor, DHTR, Dihydrotestosterone receptor, NR3C4
  • UniProt Gene Name
    AR
  • UniProtKB
    P10275
Application Images
Image 1 Immunohistochemistry analysis of Formalin-fixed, paraffin-embedded Human Prostate using Androgen Receptor antibody.
Image 2 Immunohistochemistry analysis of Formalin-fixed, paraffin-embedded Human Prostate using Androgen Receptor antibody.
Image 3 Immunohistochemistry analysis of Formalin-fixed, paraffin-embedded Human Prostatic carcinoma using Androgen Receptor antibody.
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