for smooth muscles is a type of cytoskeletal proteins commonly expressed in
eukaryotes. They mainly help in regulation of different functions of cells
including contraction of muscle tissues, synthesis of mRNA, apoptosis etc.
This product is the actin isoform, which is predominantly found in the
cardiac tissues of the adults. Any modifications in this isoform have already
been related to congenital heart diseases and hypertrophic
Smooth muscle gamma-actin is present primarily in the form of a fibrous polymer. In response to signals from cytoskeletal reorganization procedures like stress, endocytosis or cytokinesis, cofilin boosts the depolymerization and fragmentation of F-actin. This causes a rise in the G-actin, a globular monomeric form of the protein.
F-actin fragments are stabilized by the ARP2/3 complex to promote the development of a new actin filament. Further studies have indicated that actin is often hyperphosphorylated in the breast tumors of primary stage. In vitro apoptotic cleavage of actin can be seen in skeletal and cardiac muscle tissues. Acceleration of caspase-3 mediated cleavage of actin is possible by ubiquitin or proteasome influenced proteolysis.
|Image 1||Immunohistochemistry analysis of Formalin-fixed, paraffin-embedded Human Cardiac muscle using Actin-pan antibody.|
|Image 2||Immunohistochemistry analysis of Formalin-fixed, paraffin-embedded Human Colon using Actin-pan antibody.|
|Image 3||Immunohistochemistry analysis of Formalin-fixed, paraffin-embedded Human Colon using Actin-pan antibody.|
|Image 4||Immunohistochemistry analysis of Formalin-fixed, paraffin-embedded Human Colon using Actin-pan antibody.|
|Image 6||Immunohistochemistry analysis of Formalin-fixed, paraffin-embedded Human Skeletal muscle using Actin-pan antibody.|