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Anti-Actin pan antibody [ABT-ACTN]

Catalog No : V0005
  • Applications
    IHC, WB
  • Host Species
    Mouse
  • Reactivity
    Human
  • Size
    50ul
  • Price
    $195.00
Actin for smooth muscles is a type of cytoskeletal proteins commonly expressed in eukaryotes. They mainly help in regulation of different functions of cells including contraction of muscle tissues, synthesis of mRNA, apoptosis etc. This product is the actin isoform, which is predominantly found in the cardiac tissues of the adults. Any modifications in this isoform have already been related to congenital heart diseases and hypertrophic cardiomyopathy.

Smooth muscle gamma-actin is present primarily in the form of a fibrous polymer. In response to signals from cytoskeletal reorganization procedures like stress, endocytosis or cytokinesis, cofilin boosts the depolymerization and fragmentation of F-actin. This causes a rise in the G-actin, a globular monomeric form of the protein.

F-actin fragments are stabilized by the ARP2/3 complex to promote the development of a new actin filament. Further studies have indicated that actin is often hyperphosphorylated in the breast tumors of primary stage. In vitro apoptotic cleavage of actin can be seen in skeletal and cardiac muscle tissues. Acceleration of caspase-3 mediated cleavage of actin is possible by ubiquitin or proteasome influenced proteolysis.
Details
  • Product Name
    Anti-Actin pan antibody [ABT-ACTN]
  • Catalog No
    V0005
  • Description
    Mouse monoclonal [ABT-ACTN] antibody to ACTN
  • Applications
    IHC, WB
  • Clonality
    Monoclonal
  • Host Species
    Mouse
  • Reactivity
    Human
  • ABT Clone ID
    ABT-ACTN
  • Antigen Retrieval
    Heat-induced epitope retrieval (HIER)
  • Concentration
    0.6mg/ml
  • Dilution
    1:50-200
  • IHC Recommended control
    Normal Colon, Cardiac muscle, Skeletal muscle
  • IHC Target Name
    Actin pan
  • Immunogen
    Synthetic peptide
  • Localization
    Cytoplasmic
  • Purification
    Immunogen affinity purified
  • Retrieval buffer
    Citrate buffer of pH6.0
  • Source/Ig Isotype
    Mouse IgG
  • Storage/Stablility
    -20°C/1 year
  • UniProtKB
    PAN
  • Volume
    2ml
Application Images
Image 1 Immunohistochemistry analysis of Formalin-fixed, paraffin-embedded Human Cardiac muscle using Actin-pan antibody.
Image 2 Immunohistochemistry analysis of Formalin-fixed, paraffin-embedded Human Colon using Actin-pan antibody.
Image 3 Immunohistochemistry analysis of Formalin-fixed, paraffin-embedded Human Colon using Actin-pan antibody.
Image 4 Immunohistochemistry analysis of Formalin-fixed, paraffin-embedded Human Colon using Actin-pan antibody.
Image 5 Immunohistochemistry analysis of Formalin-fixed, paraffin-embedded Human Colon using Actin-pan antibody.
Image 6 Immunohistochemistry analysis of Formalin-fixed, paraffin-embedded Human Skeletal muscle using Actin-pan antibody.
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